Technologies available to researchers at Boehringer Ingelheim RCV GmbH & Co KG cover flow cytometry and cell sorting, a wide variety of microscopical techniques (including confocal laser scanning microscopy), image analysis and processing as well as laser-capture microdissection.
Flow cytometry is mainly used to determine the expression of potential drug targets on cultered cells or to investigate the impact of new drugs on cellular physiology, e.g. cell cycle.
Investigation of the expression of tumor markers and surrogate markers for drug action is a main focus of histological or immunohistochemical analyses of tumor tissues by light microscopy.
Confocal laser scanning microscopy is applied to elucidate drug action at the subcellular level.